Applications
Anywhere cells are grown outside the body.
The matrix is not only a cell therapy problem. It is a cell culture problem, and it shows up in routine work long before it shows up in a clinic.
2D and 3D culture
Replace an undefined coating with a material whose composition you know and can reorder unchanged.
Organoids and disease models
Control the mechanical and adhesive environment that drives organoid formation, instead of inheriting it from a tumour extract.
Differentiation
Stiffness and ligand presentation steer lineage choice. Design them rather than discover them.
Drug screening and toxicology
A defined matrix removes one of the larger sources of plate to plate variability in phenotypic assays.
Immune cell expansion
Tune the material context that supports expansion and phenotype retention.
Tissue engineering
Scaffolds designed against a target mechanical and degradation profile rather than selected from stock.
Regenerative cell therapy
Where the material stops being a convenience and starts deciding whether the therapy works at all.
Read moreSome workflows tolerate a bad matrix. Others do not.
In routine culture an imperfect material costs you some variability. In transplantation it costs you the experiment, and eventually the therapy. The further a workflow sits toward the right of this ordering, the more the material decides the outcome.
Schematic ordering of how sensitive each workflow is to the material environment. Illustrative only.